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Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta‐analysis

artikel dosen Jumat, 22 Maret 2019

Systematic review and meta‐analyses to study the robustness of observations that treatment of periodontitis improves the atherosclerotic profile.

Material and Methods

Literature was searched in Medline‐PubMed, Cochrane CENTRAL and EMBASE, based on controlled periodontal intervention trials, including also a non‐intervention group. Data were extracted and meta‐analyses were performed.

Results

From 3928 screened studies, 25 trials met the eligibility criteria. These trials enrolled 1748 periodontitis patients. Seven trials enrolled periodontitis patients that were otherwise healthy, 18 trials recruited periodontal patients with various co‐morbidities, such as CVD or diabetes. None of the trials used hard clinical endpoints of CVD. However, improvement of endothelial function has been consistently reported. Meta‐analyses demonstrated significant weighted mean difference (WMD) for hsCRP (−0.50 mg/l … drg. Hendri Susanto: https://scholar.google.co.id/citations?hl=en&user=dnSnZLIAAAAJ

Two Flavonoid Compounds as Antiproliferative Activity Against SP-C1 Cancer Tongue Cells from the Leaves of Rasamala (Altingia excelsa Nornha)

artikel dosen Jumat, 22 Maret 2019

Two flavonoid compounds, kaempferol (1) and quercetin (2) have been isolated from the leaves of Rasamala (Altingia excelsa Nornha). The chemical structure of compounds 1 and 2 were identified by spectroscopic evidences including, UV, IR, 1D-NMR, 2D-NMR and MS as well as by comparing with previously reported spectral data. These compounds were isolated from this plant for the first time. Compounds 1 and 2 were evaluated for their antiproliferative activity against SP-C1 cancer tongue cells and showed IC 50 values of 2.50 and 2.31 mM, respectively. read more