Systematic review and meta‐analyses to study the robustness of observations that treatment of periodontitis improves the atherosclerotic profile.

Material and Methods

Literature was searched in Medline‐PubMed, Cochrane CENTRAL and EMBASE, based on controlled periodontal intervention trials, including also a non‐intervention group. Data were extracted and meta‐analyses were performed.

Results

From 3928 screened studies, 25 trials met the eligibility criteria. These trials enrolled 1748 periodontitis patients. Seven trials enrolled periodontitis patients that were otherwise healthy, 18 trials recruited periodontal patients with various co‐morbidities, such as CVD or diabetes. None of the trials used hard clinical endpoints of CVD. However, improvement of endothelial function has been consistently reported. Meta‐analyses demonstrated significant weighted mean difference (WMD) for hsCRP (−0.50 mg/l … drg. Hendri Susanto: https://scholar.google.co.id/citations?hl=en&user=dnSnZLIAAAAJ